Clinical Science

As part of the AO ITC, together with Clinical Operations, we are the AO's clinical research provider. Clinical evidence generated through AO clinical studies can be accessed in the form of journal articles, presentations at scientific meetings, final study reports, guidelines, classifications, and/or news on the AO website. AO ITC Clinical Science Advisory Commission (CSAC) provides strategic advice for clinical evidence generation.

Who we are

Together with Clinical Operations, we are a team of about 30 clinical research specialists (project managers, medical advisers, medical statisticians, data mangers, clinical research associates, study assistance, image research associates, medical writers and quality and regulatory managers) we produce clinical evidence that is highly relevant to current trauma and orthopedics practices for better patient care.

What we do

We provide medical and scientific support for AO clinical studies and conduct health economics projects in collaboration with a network of renowned health economics experts.


Browse our peer-reviewed publications.


Find out about clinical research fellowships.

AO Innovation Translation Center - Clinical Science

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Clinical Evidence

AO ITC clinical research to global standards (ISO 14155 and ICH GCP), drawing on in-house medical and scientific expertise.

Innovation translation

Innovation translation at the AO involves developing disruptive technologies to address unmet clinical needs.

Completed Studies

We transform ideas into clinical study protocols. AO clinical studies are divided into 5 phases: idea, planning, monitoring, analysis, and publication.

Clinical evidence: Central to the AO's history

In 1959, Maurice E Müller, a founding member of the AO Foundation, created the AO Documentation Center to share experience and validate the AO methods. In 1967, the AO Documentation Center was formally registered in Bern, Switzerland, as a foundation for the purpose of collecting, analyzing, and evaluation of fracture handling/osteosyntheses.

In 1995, the AO Documentation Center was registered in Canton Graubünden and renamed AO Documentation and Publishing Foundation. Today, this is an essential part of the AO Innovation Translation Center.